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Who was studied 16,595 European ancestry cases, 523,330 European ancestry controls.
The effect
Each copy of the G allele carried 1.11 times the odds of Uterine fibroids (95% confidence interval 1.08-1.14); p = 3 × 10−13.
How common The G allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 22, band 22q13.1 — in an intron of TNRC6B.
What each result means
G/GTwo copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 30194396 · open access
Questions about rs12484951
What is rs12484951?
rs12484951 is a single position in the genome, in or near the TNRC6B gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12484951 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs12484951 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12484951 come from?
GWAS Catalog, Nature communications 2018, PMID:30194396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 812212Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot2Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others2Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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