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Waist-hip index

RN7SKP33 · rs12481092

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁶, with 9 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 186,825 British ancestry men.

The effect Each copy of the T allele shifted the measure 0.0294 lower (95% confidence interval 0.022-0.036); p = 1 × 10⁻¹⁶.

Where it sits Chromosome 20, band 20q13.12 — between genes, 1.2 kb from RN7SKP33.

How common each version is

CT

By ancestry gnomAD

East Asian

C 98.9% · T 1.1%

European (non-Finnish)

C 73.5% · T 26.6%

African / African American

C 88.3% · T 11.7%

South Asian

C 86.4% · T 13.6%

Admixed American (Latino)

C 82.0% · T 18.0%

Middle Eastern

C 83.2% · T 16.8%

Finnish

C 67.6% · T 32.4%

Ashkenazi Jewish

C 79.3% · T 20.7%

The share of all copies of this position that are each version. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C No copy of the version the research linked to Waist-hip index. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Waist-hip index. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Waist-hip index. That is the strongest link of the three results. A link in a study is not a diagnosis.

DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.

Source

GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer

Christakoudi S, Evangelou E, Riboli E, Tsilidis KK

Scientific reports · 2021 · PMID 34021172 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Waist-hip index (rs12481092). MyGeneLog™. https://www.mygenelog.com/variants/rs12481092

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