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Age at menopause

YIPF4 · rs12470495

Where this position leads

Condition: Age at Menopause

What the study found

Who was studied 181,219 European ancestry individuals, 43,861 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.09 higher; p = 3 × 10⁻¹⁰.

How common The A allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 2, band 2p22.3 — in an intron of YIPF4.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Age at menopause compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Age at menopause.

G/G Published research associates this genotype with typical/baseline likelihood of Age at menopause — no copies of the reported risk allele.

Source

Joint Genome-Wide Association Analyses Identified 49 Novel Loci For Age at Natural Menopause

Zhang L, Wei XT, Niu JJ, Lin ZX, Xu Q, Ni JJ, Zhang WL, Han BX, Yan SS, Feng GJ, Zhang H, Yang XL

and 5 more — show all

Zhang ZJ, Hai R, Ren HG, Zhang F, Pei YF

The Journal of clinical endocrinology and metabolism · 2021 · PMID 34050765

Questions about rs12470495

What is rs12470495?

rs12470495 is a single position in the genome, in or near the YIPF4 gene. Published research associates it with age at menopause. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12470495 linked to?

On MyGeneLog this position is linked to Age at Menopause. The research behind each link, and its sources, are set out on that condition page.

Does having rs12470495 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12470495 come from?

GWAS Catalog, The Journal of clinical endocrinology and metabolism 2021, PMID:34050765. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Age at menopause (rs12470495). MyGeneLog™. https://www.mygenelog.com/variants/rs12470495

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