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Who was studied 15,302 Japanese ancestry cases, 36,140 Japanese ancestry controls.
The effect
Each copy of the A allele carried 1.28 times the odds of Coronary artery disease (95% confidence interval 1.19-1.38); p = 1 × 10−10.
How common The A allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 2, band 2p24.1 — between genes, 52.1 kb from NUTF2P8.
What each result means
A/ATwo copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Circulation. Genomic and precision medicine · 2020 · PMID 32469254
Questions about rs12469758
What is rs12469758?
rs12469758 is a single position in the genome, in or near the TDRD15 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12469758 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12469758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12469758 come from?
GWAS Catalog, Circulation. Genomic and precision medicine 2020, PMID:32469254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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