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Standard

Height

DNM2 · rs12459870

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−31, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 472,730 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0306 lower (95% confidence interval 0.026-0.036); p = 5 × 10−32.

How common The T allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 19, band 19p13.2 — in an intron of DNM2.

How common each version is

CT
Korean KRGDB
C 63.7% · T 36.3%
Korean Korea4K
C 64.3% · T 35.7%
Korean Korea1K
C 63.4% · T 36.6%
Japanese ToMMo
C 63.6% · T 36.4%
Vietnamese
C 80.8% · T 19.2%
World gnomAD
C 94.3% · T 5.7%
World 1000 Genomes
C 89.1% · T 10.9%
World TOPMed
C 93.8% · T 6.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Height (rs12459870). MyGeneLog™. https://www.mygenelog.com/variants/rs12459870

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