0 3217123117Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total32Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 954 African American individuals; replicated in 480 African American individuals.
The effect
Each copy of the C allele shifted the measure 0.59 higher (95% confidence interval 0.50-0.68); p = 1 × 10−39.
Where it sits Chromosome 19, band 19q13.2 — between genes, 7.2 kb from CYP2F2P.
What each result means
C/CTwo copies of the version the research linked to Nicotine metabolite ratio in current smokers. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Nicotine metabolite ratio in current smokers. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Nicotine metabolite ratio in current smokers. This is the starting point the study compared everyone against.
rs12459249 is a single position in the genome, in or near the CYP2A6 gene. Published research associates it with nicotine metabolite ratio in current smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs12459249 affect how medicines work?
CYP2A6 carries pharmacogenomic findings for Smoking cessation medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs12459249 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12459249 come from?
GWAS Catalog, Addiction 2017, PMID:28921760. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 3217123117Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total32Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Nicotine metabolite ratio in current smokers (rs12459249). MyGeneLog™. https://www.mygenelog.com/variants/rs12459249