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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 10,308 African American or Afro-Caribbean cases, 98,448 African American or Afro-Caribbean controls, 5,110 Hispanic or Latin American cases, 48,838 Hispanic or Latin American controls, 252 East Asian ancestry cases, 6,231 East Asian ancestry controls, 53,699 European ancestry cases, 338,014 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0511 lower (95% confidence interval 0.037-0.065); p = 4 × 10−11.
How common The G allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 18, band 18q11.2 — between genes, 36.9 kb from ATP7BP1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Diverticulosis (PheCode 562.1) — no copies of the reported risk allele.
C/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diverticulosis (PheCode 562.1).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diverticulosis (PheCode 562.1) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs12456453
What is rs12456453?
rs12456453 is a single position in the genome, in or near the near ATP7BP1 gene. Published research associates it with diverticulosis (phecode 562.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12456453 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12456453 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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