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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,011 African American or Afro-Caribbean cases, 115,926 African American or Afro-Caribbean controls, 2,957 Hispanic or Latin American cases, 54,828 Hispanic or Latin American controls, 254 East Asian ancestry cases, 6,420 East Asian ancestry controls, 17,425 European ancestry cases, 419,299 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0692 higher (95% confidence interval 0.047-0.091); p = 4 × 10−11.
How common The T allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 17, band 17q25.3 — in an intron of PGS1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Hyperglyceridemia (PheCode 272.12) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hyperglyceridemia (PheCode 272.12).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hyperglyceridemia (PheCode 272.12) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs12453598
What is rs12453598?
rs12453598 is a single position in the genome, in or near the PGS1 gene. Published research associates it with hyperglyceridemia (phecode 272.12). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12453598 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12453598 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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