C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyrotoxic hypokalemic periodic paralysis and Graves disease compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyrotoxic hypokalemic periodic paralysis and Graves disease.
T/TPublished research associates this genotype with typical/baseline likelihood of Thyrotoxic hypokalemic periodic paralysis and Graves disease — no copies of the reported risk allele.
JAMA network open · 2019 · PMID 31050781 · open access
Questions about rs12451295
What is rs12451295?
rs12451295 is a single position in the genome, in or near the CTD-2378E21.1 gene. Published research associates it with thyrotoxic hypokalemic periodic paralysis and graves disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12451295 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12451295 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12451295 come from?
GWAS Catalog, JAMA Netw Open 2019, PMID:31050781. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.