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Who was studied 15,126 European ancestry cases, 95,725 European ancestry controls; replicated in 30,770 European ancestry cases, 286,913 European ancestry controls.
The effect
Each copy of the A allele carried 1.08 times the odds of Restless legs syndrome (95% confidence interval 1.06-1.10); p = 4 × 10−14.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 17, band 17q21.32 — in an intron of LINC02086.
What each result means
A/ATwo copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
The Lancet. Neurology · 2017 · PMID 29029846 · open access
Questions about rs12450895
What is rs12450895?
rs12450895 is a single position in the genome, in or near the HOXBcluster gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12450895 linked to?
On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs12450895 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12450895 come from?
GWAS Catalog, Lancet Neurol 2017, PMID:29029846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4211210122221Reads by AI crawlersClaude1ChatGPT1Google · Gemini0Perplexity2Meta AI10Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others21Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Restless legs syndrome (rs12450895). MyGeneLog™. https://www.mygenelog.com/variants/rs12450895