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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 397,338 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0179 higher (95% confidence interval 0.012-0.024); p = 2 × 10−9.
How common The C allele had a frequency of about 86% in the people studied.
Where it sits Chromosome 16, band 16q12.1 — in an intron of ZNF423.
What each result means
C/CTwo copies of the version the research linked to Age at first sexual intercourse. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Age at first sexual intercourse. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Age at first sexual intercourse. This is the starting point the study compared everyone against.
Nature human behaviour · 2021 · PMID 34211149 · open access
Questions about rs12448731
What is rs12448731?
rs12448731 is a single position in the genome, in or near the ZNF423 gene. Published research associates it with age at first sexual intercourse. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12448731 linked to?
On MyGeneLog this position is linked to Age at First Sexual Intercourse. The research behind each link, and its sources, are set out on that condition page.
Does having rs12448731 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12448731 come from?
GWAS Catalog, Nature human behaviour 2021, PMID:34211149. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Age at first sexual intercourse (rs12448731). MyGeneLog™. https://www.mygenelog.com/variants/rs12448731