2 4642116123125Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI6Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 10,884 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.15 lower (95% confidence interval 0.13-0.17); p = 6 × 10−27.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 16, band 16p12.3 — in an intron of PDILT.
What each result means
A/ATwo copies of the version the research linked to Urinary uromodulin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Urinary uromodulin levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Urinary uromodulin levels. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs12446492
What is rs12446492?
rs12446492 is a single position in the genome, in or near the PDILT gene. Published research associates it with urinary uromodulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs12446492?
Subjects that appear in the title or abstract of the same papers as this rsID include kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs12446492 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12446492 come from?
GWAS Catalog, J Am Soc Nephrol 2014, PMID:24578125. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4642116123125Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI6Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.