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Who was studied 10,588 European ancestry cases, 22,806 European ancestry controls.
The effect
Each copy of the C allele carried 1.16 times the odds of Psoriasis (95% confidence interval -); p = 1 × 10−16.
How common The C allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 16, band 16p11.2 — at a splice region of STX1B.
What ClinVar records
ClassificationBenign for Generalized epilepsy with febrile seizures plus, type 9, Inborn genetic diseases; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-02-04.
ClinVar record 586685NM_052874.5(STX1B):c.538-7A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Nature genetics · 2012 · PMID 23143594 · open access
Questions about rs12445568
What is rs12445568?
rs12445568 is a single position in the genome, in or near the PRSS53 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12445568 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs12445568 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12445568 come from?
GWAS Catalog, Nat Genet 2012, PMID:23143594. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4132114223122Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI4Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others22Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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