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Small vessel stroke

JPH3 · rs12445022

Where this position leads

Condition: Ischaemic Stroke

rs12445022 Condition: Ischaemic Stroke Ischaemic Stroke Condition rs12445022 rs12445022 JPH3

What the study found

Who was studied 2,275 European ancestry cases, 12,285 European ancestry controls; replicated in 1,928 European ancestry cases, 38,443 European ancestry controls.

The effect Each copy of the A allele carried 1.16 times the odds of Small vessel stroke (95% confidence interval 1.10-1.21); p = 3 × 10−9.

How common The A allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 16, band 16q24.2 — in a regulatory region of LOC124903748.

What each result means

A/A Two copies of the version the research linked to Small vessel stroke. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Small vessel stroke. That is a smaller link than two copies.
G/G No copy of the version the research linked to Small vessel stroke. This is the starting point the study compared everyone against.
Source
Genetic variation at 16q24.2 is associated with small vessel stroke
Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD
and 55 more — show all
Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S, Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Słowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS
METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium · International Stroke Genetics Consortium
Annals of neurology · 2017 · PMID 27997041 · open access

Questions about rs12445022

What is rs12445022?

rs12445022 is a single position in the genome, in or near the JPH3 gene. Published research associates it with small vessel stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12445022 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs12445022 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12445022 come from?

GWAS Catalog, Ann Neurol 2016, PMID:27997041. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Small vessel stroke (rs12445022). MyGeneLog™. https://www.mygenelog.com/variants/rs12445022

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