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Spatial QRS-T angle

CDH13 · rs12443745

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 96,562 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.075 higher (95% confidence interval 0.057-0.093); p = 2 × 10⁻¹⁸.

How common The C allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 16, band 16q23.3 — in an intron of CDH13.

What each result means

C/C Two copies of the version the research linked to Spatial QRS-T angle. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Spatial QRS-T angle. That is a smaller link than two copies.

G/G No copy of the version the research linked to Spatial QRS-T angle. This is the starting point the study compared everyone against.

Source

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Young WJ, Haessler J, Benjamins JW, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J, Garnier S, van Duijvenboden S, Baldassari AR, Concas MP

and 82 more — show all

Duong T, Foco L, Isaksen JL, Mei H, Noordam R, Nursyifa C, Richmond A, Santolalla ML, Sitlani CM, Soroush N, Thériault S, Trompet S, Aeschbacher S, Ahmadizar F, Alonso A, Brody JA, Campbell A, Correa A, Darbar D, De Luca A, Deleuze JF, Ellervik C, Fuchsberger C, Goel A, Grace C, Guo X, Hansen T, Heckbert SR, Jackson RD, Kors JA, Lima-Costa MF, Linneberg A, Macfarlane PW, Morrison AC, Navarro P, Porteous DJ, Pramstaller PP, Reiner AP, Risch L, Schotten U, Shen X, Sinagra G, Soliman EZ, Stoll M, Tarazona-Santos E, Tinker A, Trajanoska K, Villard E, Warren HR, Whitsel EA, Wiggins KL, Arking DE, Avery CL, Conen D, Girotto G, Grarup N, Hayward C, Jukema JW, Mook-Kanamori DO, Olesen MS, Padmanabhan S, Psaty BM, Pattaro C, Ribeiro ALP, Rotter JI, Stricker BH, van der Harst P, van Duijn CM, Verweij N, Wilson JG, Orini M, Charron P, Watkins H, Kooperberg C, Lin HJ, Wilson JF, Kanters JK, Sotoodehnia N, Mifsud B, Lambiase PD, Tereshchenko LG, Munroe PB

Nature communications · 2023 · PMID 36918541 · open access

Questions about rs12443745

What is rs12443745?

rs12443745 is a single position in the genome, in or near the CDH13 gene. Published research associates it with spatial qrs-t angle. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12443745 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12443745 come from?

GWAS Catalog, Nature communications 2023, PMID:36918541. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Spatial QRS-T angle (rs12443745). MyGeneLog™. https://www.mygenelog.com/variants/rs12443745

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