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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 390,964 European ancestry individuals; replicated in 105,030 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 7.26 z-score higher; p = 4 × 10−13.
How common The G allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 15, band 15q26.1 — in an intron of SEMA4B.
What each result means
C/CNo copy of the version the research linked to Serum alkaline phosphatase levels. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Serum alkaline phosphatase levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Serum alkaline phosphatase levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33547301 · open access
Questions about rs12438213
What is rs12438213?
rs12438213 is a single position in the genome, in or near the SEMA4B gene. Published research associates it with serum alkaline phosphatase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12438213 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12438213 come from?
GWAS Catalog, Nature communications 2021, PMID:33547301. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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