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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 89,579 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0469 higher (95% confidence interval 0.033-0.061); p = 4 × 10−16.
Where it sits Chromosome 12, band 12q13.11 — in an intron of RAPGEF3.
What each result means
C/CNo copy of the version the research linked to Vertical cup-disc ratio. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Vertical cup-disc ratio. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Vertical cup-disc ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
American journal of human genetics · 2021 · PMID 34077760 · open access
Questions about rs12426774
What is rs12426774?
rs12426774 is a single position in the genome, in or near the RAPGEF3 gene. Published research associates it with vertical cup-disc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12426774 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12426774 come from?
GWAS Catalog, American journal of human genetics 2021, PMID:34077760. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Vertical cup-disc ratio (rs12426774). MyGeneLog™. https://www.mygenelog.com/variants/rs12426774