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Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0415 lower (95% confidence interval 0.035-0.048); p = 1 × 10−32.
How common The T allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 12, band 12q21.2 — between genes, 113.6 kb from RN7SL734P.
What each result means
C/CNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs12426691
What is rs12426691?
rs12426691 is a single position in the genome, in or near the near RN7SL734P gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12426691 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs12426691 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12426691 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1312217Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total13Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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