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Who was studied 2,853 European ancestry cases and 37,405 European ancestry controls; replicated in 1,827 European ancestry cases and 2,181 European ancestry controls.
The effect
Each copy of the G allele carried 1.15 times the odds of Vitiligo (95% confidence interval 1.1-1.2); p = 5 × 10−8.
How common The G allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 11, band 11q13.1 — in an intron of PLCB3.
What each result means
A/ANo copy of the version the research linked to Vitiligo. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Vitiligo. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Vitiligo. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2016 · PMID 27723757 · open access
Questions about rs12421615
What is rs12421615?
rs12421615 is a single position in the genome, in or near the PPP1R14B gene. Published research associates it with vitiligo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12421615 linked to?
On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.
Does having rs12421615 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12421615 come from?
GWAS Catalog, Nat Genet 2016, PMID:27723757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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