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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.014 lower (95% confidence interval 0.0099-0.0182); p = 5 × 10−12.
How common The G allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 11, band 11q13.1 — inside CFL1.
What each result means
A/ANo copy of the version the research linked to Urate levels (UKB data field 30880). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Urate levels (UKB data field 30880). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Urate levels (UKB data field 30880). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs12419727
What is rs12419727?
rs12419727 is a single position in the genome, in or near the CFL1 gene. Published research associates it with urate levels (ukb data field 30880). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12419727 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12419727 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12419727 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 9324Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon3Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others4Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Urate levels (UKB data field 30880) (rs12419727). MyGeneLog™. https://www.mygenelog.com/variants/rs12419727