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Intraocular pressure

EXOC6 · rs12413181

Where this position leads

Condition: Intraocular Pressure

rs12413181 Condition: Intraocular Pressure Intraocular Pressure Condition rs12413181 rs12413181 EXOC6

What the study found

Who was studied 101,939 European ancestry cases.

The effect Each copy of the A allele shifted the measure 0.17 higher (95% confidence interval 0.11-0.23); p = 2 × 10−11.

Where it sits Chromosome 10, band 10q23.33 — in an intron of EXOC6.

What each result means

A/A Two copies of the version the research linked to Intraocular pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Intraocular pressure. That is a smaller link than two copies.
G/G No copy of the version the research linked to Intraocular pressure. This is the starting point the study compared everyone against.
Source

Questions about rs12413181

What is rs12413181?

rs12413181 is a single position in the genome, in or near the EXOC6 gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12413181 linked to?

On MyGeneLog this position is linked to Intraocular Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs12413181 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12413181 come from?

GWAS Catalog, JAMA ophthalmology 2020, PMID:32352494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intraocular pressure (rs12413181). MyGeneLog™. https://www.mygenelog.com/variants/rs12413181

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