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Who was studied 342,286 European ancestry individuals, 6,015 African ancestry individuals, 7,336 South Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.049 lower (95% confidence interval 0.036-0.062); p = 7 × 10−14.
Where it sits Chromosome 1, band 1q22 — in an intron of MSTO1.
What each result means
A/ANo copy of the version the research linked to Urea levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Urea levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Urea levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs12407219
What is rs12407219?
rs12407219 is a single position in the genome, in or near the MSTO1 gene. Published research associates it with urea levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12407219 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs12407219 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12407219 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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