FMO3 · rs12406572
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 6,540 Bangladeshi ancestry individuals.
The effect Each copy of the A allele shifted the measure 1.3 percentage points lower; p = 3 × 10−16.
How common The A allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 1, band 1q24.3 — in an intron of FMO3.
2025-09-02 · Tamayo LI et al. Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans. PLoS Genetics 2025, PMID:40892834
Arsenic in drinking water: new genes that change how the body clears it
In Bangladesh more than fifty million people are chronically exposed to arsenic through their drinking water. How well a person breaks arsenic down was already known to depend on the AS3MT and FTCD gene regions; this study of urine from 6,540 people and blood from 976 found new signals in the FMO gene cluster, led by FMO3 and FMO4, and in GSTO1. The new positions did not show a clear association with arsenic-induced skin lesions. Four of the study's positions have pages here, including rs12406572 in FMO3 and rs34521730 in GSTO1. PMID:40892834.
rs12406572 is a single position in the genome, in or near the FMO3 gene. Published research associates it with urinary monomethylated arsenic species percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS genetics 2025, PMID:40892834. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Urinary monomethylated arsenic species percentage (rs12406572). MyGeneLog™. https://www.mygenelog.com/variants/rs12406572