NPPB · rs12406089
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,932 Finnish ancestry individuals; replicated in 1,373 Finnish ancestry individuals.
The effect Each copy of the G allele shifted the measure 0.201 Unit higher (95% confidence interval 0.17-0.23); p = 8 × 10−48.
How common The G allele had a frequency of about 71% in the people studied.
Where it sits Chromosome 1, band 1p36.22 — between genes, 2.1 kb from NPPB.
rs12406089 is a single position in the genome, in or near the NPPB gene. Published research associates it with n-terminal pro b-type natriuretic peptide levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Circ Cardiovasc Genet 2017, PMID:29237677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.