near SEPTIN14P21 · rs12405634
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,163 Sub-Saharan African ancestry individuals; replicated in 1,263 African American individuals.
The effect Each copy of the T allele shifted the measure 0.311 lower (95% confidence interval 0.23-0.4); p = 8 × 10−13.
Where it sits Chromosome 1, band 1q43 — between genes, 108.1 kb from SEPTIN14P21.
rs12405634 is a single position in the genome, in or near the near SEPTIN14P21 gene. Published research associates it with leptin levels in overweight individuals. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genome medicine 2021, PMID:34620218. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Leptin levels in overweight individuals (rs12405634). MyGeneLog™. https://www.mygenelog.com/variants/rs12405634