C/CPublished research associates this genotype with typical/baseline likelihood of Neuroticism — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism compared to the general population.
Molecular psychiatry · 2016 · PMID 27067015 · open access
Questions about rs12378446
What is rs12378446?
rs12378446 is a single position in the genome, in or near the PTRD gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12378446 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs12378446 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12378446 come from?
GWAS Catalog, Mol Psychiatry 2016, PMID:27067015. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.