2 4122134123122Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity3Meta AI4Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others22Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 91,370 European ancestry individuals, 15,346 individuals.
The effect
Each copy of the T allele shifted the measure 0.1 higher (95% confidence interval 0.067-0.133); p = 9 × 10−9.
How common The T allele had a frequency of about 79% in the people studied.
Where it sits Chromosome 9, band 9p23 — in an intron of LOC105375974.
What each result means
C/CNo copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2016 · PMID 27067015 · open access
Questions about rs12378446
What is rs12378446?
rs12378446 is a single position in the genome, in or near the PTRD gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12378446 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs12378446 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12378446 come from?
GWAS Catalog, Mol Psychiatry 2016, PMID:27067015. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4122134123122Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity3Meta AI4Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others22Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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