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Who was studied 51,378 European ancestry cases, 243,913 European ancestry controls.
The effect
Each copy of the C allele carried 0.95 times the odds of ICD10 D25: Leiomyoma of uterus (95% confidence interval 0.93-0.96); p = 1 × 10−12.
Where it sits Chromosome 4, band 4q23 — in an intron of METAP1.
What each result means
C/CTwo copies of the version the research linked to ICD10 D25: Leiomyoma of uterus. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to ICD10 D25: Leiomyoma of uterus. That is a smaller link than two copies.
T/TNo copy of the version the research linked to ICD10 D25: Leiomyoma of uterus. This is the starting point the study compared everyone against.
rs12374261 is a single position in the genome, in or near the METAP1 gene. Published research associates it with icd10 d25: leiomyoma of uterus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12374261 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs12374261 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12374261 come from?
GWAS Catalog, Nature medicine 2025, PMID:40069456. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 61122Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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ICD10 D25: Leiomyoma of uterus (rs12374261). MyGeneLog™. https://www.mygenelog.com/variants/rs12374261