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Who was studied 17,881 European ancestry female cases, 219,656 European ancestry female controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 3 × 10−10.
Where it sits Chromosome 10, band 10q26.13 — between genes, 25.2 kb from ATE1.
What each result means
A/ANo copy of the version the research linked to Breast cancer. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Breast cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2020 · PMID 32887889 · open access
Questions about rs12354821
What is rs12354821?
rs12354821 is a single position in the genome, in or near the near ATE1 gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12354821 linked to?
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs12354821 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12354821 come from?
GWAS Catalog, Nature communications 2020, PMID:32887889. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Breast cancer (rs12354821). MyGeneLog™. https://www.mygenelog.com/variants/rs12354821