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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 125,000 African ancestry individuals (MTAG boosted by high-density lipoprotein and triglyceride samples).
The effect
Each copy of the A allele shifted the measure 0.024 lower (95% confidence interval 0.017-0.031); p = 2 × 10−11.
Where it sits Chromosome 9, band 9p22.3 — in an intron of TTC39B.
What each result means
A/ATwo copies of the version the research linked to Total cholesterol levels (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Total cholesterol levels (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Total cholesterol levels (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37669986 · open access
Questions about rs12348997
What is rs12348997?
rs12348997 is a single position in the genome, in or near the TTC39B gene. Published research associates it with total cholesterol levels (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12348997 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12348997 come from?
GWAS Catalog, Nature communications 2023, PMID:37669986. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total cholesterol levels (MTAG) (rs12348997). MyGeneLog™. https://www.mygenelog.com/variants/rs12348997