Gene Knowledge Graph
UTC
Sensitive

Lung adenocarcinoma

near MTAP · rs12348845

Where this position leads

Condition: EGFR Mutation-Positive Lung Adenocarcinoma

rs12348845 Condition: EGFR Mutation-Positive Lung Adenocarcinoma EGFR Mutation-Positive Lung Adenoca… Condition rs12348845 rs12348845 near MTAP

What the study found

Who was studied 9,791 European ancestry cases, 23,173 European ancestry controls, 4,630 East Asian ancestry cases, 5,372 East Asian ancestry controls, 844 African American cases, 3,774 African American controls; replicated in 3,095 European ancestry cases, 436,443 European ancestry controls, 8,755 East Asian ancestry cases, 13,324 East Asian ancestry controls, 186 African American cases, 560 African American controls.

The effect Each copy of the A allele shifted the measure 0.13 higher (95% confidence interval 0.091-0.169); p = 3 × 10−19.

Where it sits Chromosome 9, band 9p21.3 — between genes, 27.1 kb from MTAP.

What each result means

A/A Two copies of the version the research linked to Lung adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Lung adenocarcinoma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Lung adenocarcinoma. This is the starting point the study compared everyone against.
Source
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z
and 73 more — show all
Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov I, Gorlova O, Zhu D, Rosenberg SM, Pinney S, Bailey-Wilson JE, Mandal D, de Andrade M, Gaba C, Willey JC, You M, Anderson M, Wiencke JK, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojeson S, Brenner H, Landi MT, Chanock SJ, Johansson M, Muley T, Risch A, Wichmann HE, Bickeböller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Andrew AS, Kiemeney LA, Shen H, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lan Q, Rothman N, Taylor F, Kachuri L, Witte JS, Sakoda LC, Spitz M, Brennan P, Lin X, McKay J, Hung RJ, Amos CI
Nature genetics · 2022 · PMID 35915169

Questions about rs12348845

What is rs12348845?

rs12348845 is a single position in the genome, in or near the near MTAP gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12348845 linked to?

On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs12348845 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12348845 come from?

GWAS Catalog, Nature genetics 2022, PMID:35915169. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung adenocarcinoma (rs12348845). MyGeneLog™. https://www.mygenelog.com/variants/rs12348845

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