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Birth weight

NTRK2 · rs12340987

Where this position leads

What the study found

Who was studied 4,593 European ancestry female twins; replicated in 3,033 European ancestry female twins, 1,418 European ancestry females, 1,579 European ancestry males.

The effect Each copy of the A allele shifted the measure 0.13 lower (95% confidence interval 0.091-0.169); p = 1 × 10⁻⁸.

How common The A allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 9, band 9q21.33 — between genes, 3.7 kb from UBE2V1P10.

What each result means

A/A Two copies of the version the research linked to Birth weight. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Birth weight. That is a smaller link than two copies.

G/G No copy of the version the research linked to Birth weight. This is the starting point the study compared everyone against.

Source

Variants close to NTRK2 gene are associated with birth weight in female twins

Metrustry SJ, Edwards MH, Medland SE, Holloway JW, Montgomery GW, Martin NG, Spector TD, Cooper C, Valdes AM

Twin research and human genetics : the official journal of the International Society for Twin Studies · 2014 · PMID 24950379

What people read about alongside this

Blood sugar and insulin1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12340987

What is rs12340987?

rs12340987 is a single position in the genome, in or near the NTRK2 gene. Published research associates it with birth weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12340987 linked to?

On MyGeneLog this position is linked to Birth Weight. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs12340987?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12340987 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12340987 come from?

GWAS Catalog, Twin Res Hum Genet 2014, PMID:24950379. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Birth weight (rs12340987). MyGeneLog™. https://www.mygenelog.com/variants/rs12340987

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