Standard
Myeloproliferative neoplasms
JAK2 · rs12339666
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype with typical/baseline likelihood of Myeloproliferative neoplasms — no copies of the reported risk allele.
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Myeloproliferative neoplasms.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Myeloproliferative neoplasms compared to the general population.
Source
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms
Tapper W,
Jones AV,
Kralovics R,
Harutyunyan AS,
Zoi K,
Leung W,
Godfrey AL,
Guglielmelli P,
Callaway A,
Ward D,
Aranaz P,
White HE
and 38 more — show all
Waghorn K,
Lin F,
Chase A,
Baxter EJ,
Maclean C,
Nangalia J,
Chen E,
Evans P,
Short M,
Jack A,
Wallis L,
Oscier D,
Duncombe AS,
Schuh A,
Mead AJ,
Griffiths M,
Ewing J,
Gale RE,
Schnittger S,
Haferlach T,
Stegelmann F,
Döhner K,
Grallert H,
Strauch K,
Tanaka T,
Bandinelli S,
Giannopoulos A,
Pieri L,
Mannarelli C,
Gisslinger H,
Barosi G,
Cazzola M,
Reiter A,
Harrison C,
Campbell P,
Green AR,
Vannucchi A,
Cross NC
Nature communications · 2015 · PMID 25849990 · open access
Questions about rs12339666
What is rs12339666?
rs12339666 is a single position in the genome, in or near the JAK2 gene. Published research associates it with myeloproliferative neoplasms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12339666 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12339666 come from?
GWAS Catalog, Nat Commun 2015, PMID:25849990. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants