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White matter integrity (mean diffusivity)

ZFP57 · rs1233587

What the study found

Who was studied 17,467 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.326 lower (95% confidence interval 0.23-0.42); p = 6 × 10−12.

How common The T allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 19.1 kb from RPSAP2.

What each result means

A/A No copy of the version the research linked to White matter integrity (mean diffusivity). This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to White matter integrity (mean diffusivity). That is a smaller link than two copies.
T/T Two copies of the version the research linked to White matter integrity (mean diffusivity). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1233587

What is rs1233587?

rs1233587 is a single position in the genome, in or near the ZFP57 gene. Published research associates it with white matter integrity (mean diffusivity). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1233587 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1233587 come from?

GWAS Catalog, Nature communications 2020, PMID:32358547. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White matter integrity (mean diffusivity) (rs1233587). MyGeneLog™. https://www.mygenelog.com/variants/rs1233587

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