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Dietary choline requirement (PEMT promoter variant)

PEMT · rs12325817

Where this position leads

Supplement: Choline

rs12325817 Supplement: Choline Choline Supplement rs12325817 rs12325817 PEMT

What each result means

C/C Carries two copies of the PEMT -744C allele. In the same study of premenopausal women, 80% with two copies developed organ dysfunction on a very-low-choline diet.
G/C Carries one copy of the PEMT -744C allele. In the same study of premenopausal women, 43% with one copy developed organ dysfunction on a very-low-choline diet — more than three times the rate seen with no copies.
G/G No copy of the PEMT -744C allele. In a study of premenopausal women fed a very-low-choline diet, 13% with this genotype developed organ dysfunction.
Talk to a doctor or a registered dietitian about choline intake, especially if pregnant, breastfeeding, or eating a diet very low in eggs, meat and other choline-rich foods.
Source
Dietary choline requirements of women: effects of estrogen and genetic variation
Fischer LM, da Costa KA, Kwock L, Galanko J, Zeisel SH
The American journal of clinical nutrition · 2010 · PMID 20861172

Questions about rs12325817

What is rs12325817?

rs12325817 is a single position in the genome, in or near the PEMT gene. Published research associates it with dietary choline requirement (pemt promoter variant). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12325817 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12325817 come from?

Fischer et al. 2010, American Journal of Clinical Nutrition — dietary choline requirements of women: effects of estrogen and genetic variation. PMID 20861172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Dietary choline requirement (PEMT promoter variant) (rs12325817). MyGeneLog™. https://www.mygenelog.com/variants/rs12325817

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