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Thyroid stimulating hormone levels within normal range in pregnancy

LINC02454 · rs12321067

What the study found

Who was studied 67,471 Chinese ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0777 lower (95% confidence interval 0.058-0.098); p = 3 × 10−14.

How common The C allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 12, band 12q14.3 — in an intron of LINC02454.

What each result means

C/C Two copies of the version the research linked to Thyroid stimulating hormone levels within normal range in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Thyroid stimulating hormone levels within normal range in pregnancy. That is a smaller link than two copies.
G/G No copy of the version the research linked to Thyroid stimulating hormone levels within normal range in pregnancy. This is the starting point the study compared everyone against.
Source

Questions about rs12321067

What is rs12321067?

rs12321067 is a single position in the genome, in or near the LINC02454 gene. Published research associates it with thyroid stimulating hormone levels within normal range in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12321067 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12321067 come from?

GWAS Catalog, Nature communications 2024, PMID:39266554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyroid stimulating hormone levels within normal range in pregnancy (rs12321067). MyGeneLog™. https://www.mygenelog.com/variants/rs12321067

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