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Hypothyroidism

C12orf76 · rs12309446

Where this position leads

Condition: Hypothyroidism

rs12309446 Condition: Hypothyroidism Hypothyroidism Condition rs12309446 rs12309446 C12orf76

What the study found

Who was studied 98,805 European ancestry cases, 948,186 European ancestry controls, 14,588 cases, 117,082 controls; replicated in 34,835 European ancestry cases, 492,149 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.045 lower; p = 8 × 10−11.

Where it sits Chromosome 12, band 12q24.11 — in an intron of C12orf76.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Hypothyroidism — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hypothyroidism.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hypothyroidism compared to the general population.
Source
Genome-wide association study and polygenic risk prediction of hypothyroidism
Rand SA, Ahlberg G, Tragante V, Monfort LM, Zheng C, Feldt-Rasmussen U, Klose MC, Teder-Laving M, Metspalu A, Poulsen HE, Ellervik C, Nygaard B
and 18 more — show all
Erikstrup C, Bruun MT, A Jensen B, Ullum H, Brunak S, Schwinn M, Ostrowski SR, Pedersen OB, Sørensen E, Jonsdottir I, Gudbjartsson DF, Thorleifsson G, Holm H, Saevarsdottir S, Stefansson K, Salling Olesen M, Bundgaard H, Ghouse J
DBDS Genomic Consortium · Estonian Biobank Research Team · 23andMe Research Team
Nature genetics · 2025 · PMID 41238958 · open access

Questions about rs12309446

What is rs12309446?

rs12309446 is a single position in the genome, in or near the C12orf76 gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12309446 linked to?

On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.

Does having rs12309446 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12309446 come from?

GWAS Catalog, Nature genetics 2025, PMID:41238958. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hypothyroidism (rs12309446). MyGeneLog™. https://www.mygenelog.com/variants/rs12309446

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