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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 12,353 European ancestry individuals; replicated in 8,159 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0269 higher (95% confidence interval 0.014-0.039); p = 2 × 10−8.
How common The A allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 1, band 1p13.2 — in an intron of MAGI3.
What each result means
A/ATwo copies of the version the research linked to Thyroid peroxidase antibody levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Thyroid peroxidase antibody levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Thyroid peroxidase antibody levels. This is the starting point the study compared everyone against.
Bujnis MN, et al. (Nature Genetics, 2026) is newly in the GWAS Catalog, with 422 associations across 1 trait ("Hashimoto thyroiditis"). The catalogue records its sample as 47,104 cases and 1,037,695 controls. Of its 299 positions, 93 already have pages here — 20 on the Hypothyroidism page; 20 on the Hashimoto Thyroiditis page; 5 on the Thyroid Stimulating Hormone (TSH) Levels page — including rs3130552 (near PSORS1C1), rs1230666 (MAG13), rs231725 (CTLA4). Everything above is from the catalogue's records, assembled by code; the paper itself is linked. PMID:42527560.
Questions about rs1230666
What is rs1230666?
rs1230666 is a single position in the genome, in or near the MAG13 gene. Published research associates it with thyroid peroxidase antibody levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1230666 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1230666 come from?
GWAS Catalog, PLoS Genet 2014, PMID:24586183. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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