Who was studied 1,318 European, African American, Asian and other ancestry cases.
The effect
Each copy of the A allele carried 2.11 times the odds of Major coronary event in darapladib-treated cardiovascular disease (time to event) (95% confidence interval 1.61-2.78); p = 3 × 10−8.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 11, band 11p14.3 — between genes, 47.6 kb from ANO3.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Major coronary event in darapladib-treated cardiovascular disease (time to event) compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Major coronary event in darapladib-treated cardiovascular disease (time to event).
G/GPublished research associates this genotype with typical/baseline likelihood of Major coronary event in darapladib-treated cardiovascular disease (time to event) — no copies of the reported risk allele.
rs12290663 is a single position in the genome, in or near the near ANO3 gene. Published research associates it with major coronary event in darapladib-treated cardiovascular disease (time to event). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12290663 linked to?
On MyGeneLog this position is linked to Darapladib Response in Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12290663 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12290663 come from?
GWAS Catalog, PLoS One 2017, PMID:28753643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.