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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 14,734 European ancestry individuals; replicated in 1,585 European or unknown ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.122 higher (95% confidence interval 0.098-0.146); p = 1 × 10−23.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 11, band 11q24.2 — in an intron of ST3GAL4.
What each result means
A/ATwo copies of the version the research linked to CUB domain-containing protein 1 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to CUB domain-containing protein 1 levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to CUB domain-containing protein 1 levels. This is the starting point the study compared everyone against.
Nature immunology · 2023 · PMID 37563310 · open access
Questions about rs12290068
What is rs12290068?
rs12290068 is a single position in the genome, in or near the ST3GAL4 gene. Published research associates it with cub domain-containing protein 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12290068 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12290068 come from?
GWAS Catalog, Nature immunology 2023, PMID:37563310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
CUB domain-containing protein 1 levels (rs12290068). MyGeneLog™. https://www.mygenelog.com/variants/rs12290068