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Who was studied 119,715 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0679 SD lower (95% confidence interval 0.058-0.078); p = 3 × 10−41.
How common The A allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 11, band 11p11.2 — in an intron of PRDM11.
What each result means
A/ATwo copies of the version the research linked to Thyroid stimulating hormone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Thyroid stimulating hormone levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Thyroid stimulating hormone levels. This is the starting point the study compared everyone against.
Nature communications · 2020 · PMID 32769997 · open access
Questions about rs12284404
What is rs12284404?
rs12284404 is a single position in the genome, in or near the PRDM11 gene. Published research associates it with thyroid stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12284404 linked to?
On MyGeneLog this position is linked to Thyroid Stimulating Hormone (TSH) Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs12284404 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12284404 come from?
GWAS Catalog, Nature communications 2020, PMID:32769997. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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