Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia
near MRGPRF · rs12283870
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Who was studied 2,083 European ancestry individuals, 284 African ancestry individuals, 781 Hispanic or Latin American individuals, 142 Asian ancestry individuals, 267 individuals.
The effect
Each copy of the T allele carried 1.29 times the odds of Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia (95% confidence interval 1.16-1.44); p = 9 × 10−10.
Where it sits Chromosome 11, band 11q13.3 — between genes, 11.3 kb from MRGPRF.
What each result means
C/CNo copy of the version the research linked to Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
JAMA network open · 2022 · PMID 36580335 · open access
Questions about rs12283870
What is rs12283870?
rs12283870 is a single position in the genome, in or near the near MRGPRF gene. Published research associates it with elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12283870 linked to?
On MyGeneLog this position is linked to Acute Lymphoblastic Leukemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs12283870 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12283870 come from?
GWAS Catalog, JAMA network open 2022, PMID:36580335. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia (rs12283870). MyGeneLog™. https://www.mygenelog.com/variants/rs12283870