Standard
Bone mineral density (paediatric, total body less head)
PPP6R3 · rs12283755
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Bone mineral density (paediatric, total body less head) — no copies of the reported risk allele. (GWAS Catalog, Nat Commun 2017, PMID:28743860)
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Bone mineral density (paediatric, total body less head). (GWAS Catalog, Nat Commun 2017, PMID:28743860)
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Bone mineral density (paediatric, total body less head) compared to the general population. (GWAS Catalog, Nat Commun 2017, PMID:28743860)
Source
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
Medina-Gomez C,
Kemp JP,
Dimou NL,
Kreiner E,
Chesi A,
Zemel BS,
Bønnelykke K,
Boer CG,
Ahluwalia TS,
Bisgaard H,
Evangelou E,
Heppe DHM
and 22 more — show all
Bonewald LF,
Gorski JP,
Ghanbari M,
Demissie S,
Duque G,
Maurano MT,
Kiel DP,
Hsu YH,
C J van der Eerden B,
Ackert-Bicknell C,
Reppe S,
Gautvik KM,
Raastad T,
Karasik D,
van de Peppel J,
Jaddoe VWV,
Uitterlinden AG,
Tobias JH,
Grant SFA,
Bagos PG,
Evans DM,
Rivadeneira F
Nature communications · 2017 · PMID 28743860 · open access
Questions about rs12283755
What is rs12283755?
rs12283755 is a single position in the genome, in or near the PPP6R3 gene. Published research associates it with bone mineral density (paediatric, total body less head). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12283755 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12283755 come from?
GWAS Catalog, Nat Commun 2017, PMID:28743860. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants