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Thiazide-induced adverse metabolic effects in hypertensive patients

NELL-1 · rs12279250

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thiazide-induced adverse metabolic effects in hypertensive patients compared to the general population. (GWAS Catalog, Pharmacogenomics J 2013, PMID:23400010)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thiazide-induced adverse metabolic effects in hypertensive patients. (GWAS Catalog, Pharmacogenomics J 2013, PMID:23400010)
T/T Published research associates this genotype with typical/baseline likelihood of Thiazide-induced adverse metabolic effects in hypertensive patients — no copies of the reported risk allele. (GWAS Catalog, Pharmacogenomics J 2013, PMID:23400010)

Source: GWAS Catalog, Pharmacogenomics J 2013, PMID:23400010

Questions about rs12279250

What is rs12279250?

rs12279250 is a single position in the genome, in or near the NELL-1 gene. Published research associates it with thiazide-induced adverse metabolic effects in hypertensive patients. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12279250 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12279250 come from?

GWAS Catalog, Pharmacogenomics J 2013, PMID:23400010. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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