Thiazide-induced adverse metabolic effects in hypertensive patients
NELL-1 · rs12279250
0 373251922337Reads by AI crawlersClaude3ChatGPT2Google · Gemini5Perplexity1Meta AI9Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others7Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 425 European ancestry cases, 342 African American cases.
The effect
Each copy of the C allele shifted the measure 28.2 mg/dL higher (95% confidence interval 18.67-37.73); p = 7 × 10−9.
How common The C allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 11, band 11p15.1 — in an intron of NELL1.
What each result means
C/CTwo copies of the version the research linked to Thiazide-induced adverse metabolic effects in hypertensive patients. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Thiazide-induced adverse metabolic effects in hypertensive patients. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Thiazide-induced adverse metabolic effects in hypertensive patients. This is the starting point the study compared everyone against.
The pharmacogenomics journal · 2014 · PMID 23400010 · open access
Questions about rs12279250
What is rs12279250?
rs12279250 is a single position in the genome, in or near the NELL-1 gene. Published research associates it with thiazide-induced adverse metabolic effects in hypertensive patients. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12279250 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs12279250 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12279250 come from?
GWAS Catalog, Pharmacogenomics J 2013, PMID:23400010. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 373251922337Reads by AI crawlersClaude3ChatGPT2Google · Gemini5Perplexity1Meta AI9Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others7Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Thiazide-induced adverse metabolic effects in hypertensive patients (rs12279250). MyGeneLog™. https://www.mygenelog.com/variants/rs12279250