Standard
Growth differentiation factor-15 levels
near LRRC25 · rs1227734
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.
The effect
Each copy of the T allele shifted the measure 0.374 higher; p = 3 × 10−250.
How common The T allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 19, band 19p13.11 — between genes, 0.9 kb from LRRC25.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Growth differentiation factor-15 levels — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Growth differentiation factor-15 levels.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Growth differentiation factor-15 levels compared to the general population.
Source
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L,
Gustafsson S,
Wang Q,
Hansen DH,
Hedman ÅK,
Schork A,
Page K,
Zhernakova DV,
Wu Y,
Peters J,
Eriksson N,
Bergen SE
and 71 more — show all
Boutin TS,
Bretherick AD,
Enroth S,
Kalnapenkis A,
Gådin JR,
Suur BE,
Chen Y,
Matic L,
Gale JD,
Lee J,
Zhang W,
Quazi A,
Ala-Korpela M,
Choi SH,
Claringbould A,
Danesh J,
Davey Smith G,
de Masi F,
Elmståhl S,
Engström G,
Fauman E,
Fernandez C,
Franke L,
Franks PW,
Giedraitis V,
Haley C,
Hamsten A,
Ingason A,
Johansson Å,
Joshi PK,
Lind L,
Lindgren CM,
Lubitz S,
Palmer T,
Macdonald-Dunlop E,
Magnusson M,
Melander O,
Michaelsson K,
Morris AP,
Mägi R,
Nagle MW,
Nilsson PM,
Nilsson J,
Orho-Melander M,
Polasek O,
Prins B,
Pålsson E,
Qi T,
Sjögren M,
Sundström J,
Surendran P,
Võsa U,
Werge T,
Wernersson R,
Westra HJ,
Yang J,
Zhernakova A,
Ärnlöv J,
Fu J,
Smith JG,
Esko T,
Hayward C,
Gyllensten U,
Landen M,
Siegbahn A,
Wilson JF,
Wallentin L,
Butterworth AS,
Holmes MV,
Ingelsson E,
Mälarstig A
Nature metabolism · 2020 · PMID 33067605
Questions about rs1227734
What is rs1227734?
rs1227734 is a single position in the genome, in or near the near LRRC25 gene. Published research associates it with growth differentiation factor-15 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1227734 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1227734 come from?
GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Growth differentiation factor-15 levels (rs1227734). MyGeneLog™. https://www.mygenelog.com/variants/rs1227734
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