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Who was studied at least 506,594 individuals (MTAG boosted by type 2 diabetes and bone mineral density samples).
The effect
Each copy of the T allele shifted the measure 0.02 higher (95% confidence interval 0.02-0.02); p = 6 × 10−11.
How common The T allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 10, band 10q25.2 — in an intron of TCF7L2.
What each result means
G/GNo copy of the version the research linked to Periodontitis / loose teeth (MTAG). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Periodontitis / loose teeth (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Periodontitis / loose teeth (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Frontiers in endocrinology · 2022 · PMID 36778599 · open access
Questions about rs12255678
What is rs12255678?
rs12255678 is a single position in the genome, in or near the TCF7L2 gene. Published research associates it with periodontitis / loose teeth (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12255678 linked to?
On MyGeneLog this position is linked to Periodontitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs12255678 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12255678 come from?
GWAS Catalog, Frontiers in endocrinology 2022, PMID:36778599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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