Gene Knowledge Graph
UTC
Sensitive

Multiple sclerosis

IL2RA · rs12253981

Where this position leads

Condition: Multiple Sclerosis

rs12253981 Condition: Multiple Sclerosis Multiple Sclerosis Condition rs12253981 rs12253981 IL2RA

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Multiple sclerosis compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Multiple sclerosis.
T/T Published research associates this genotype with typical/baseline likelihood of Multiple sclerosis — no copies of the reported risk allele.
Source
Overexpression of the Cytokine BAFF and Autoimmunity Risk
Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E
and 69 more — show all
Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F
The New England journal of medicine · 2017 · PMID 28445677

Questions about rs12253981

What is rs12253981?

rs12253981 is a single position in the genome, in or near the IL2RA gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12253981 linked to?

On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs12253981 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12253981 come from?

GWAS Catalog, N Engl J Med 2017, PMID:28445677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants