1 17112319Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others9Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,782 Admix African and African American ancestry cases, 9,356 Admix African and African American ancestry controls, 11,350 East Asian ancestry cases, 137,515 East Asian ancestry controls, 166,322 European ancestry cases, 1,313,950 European ancestry controls, 1,774 Hispanic or Latin American cases, 7,665 Hispanic or Latin American controls, 218 South Asian ancestry cases, 413 South Asian ancestry controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Atrial fibrillation (95% confidence interval 1.04-1.07); p = 9 × 10−16.
How common The C allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 10, band 10q11.23 — between genes, 33.4 kb from TMEM273.
What each result means
C/CTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
rs12253763 is a single position in the genome, in or near the near TMEM273 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12253763 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs12253763 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12253763 come from?
GWAS Catalog, Nature genetics 2025, PMID:40050429. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 17112319Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others9Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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