Standard

HDL cholesterol levels

TRAFD1 · rs12231737

What the study found

Who was studied 58,701 Korean ancestry individuals.

The effect Each copy of the T allele shifted the measure 1.35 lower (95% confidence interval 1.16-1.54); p = 7 × 10−43.

Where it sits Chromosome 12, band 12q24.13 — in an intron of TRAFD1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of HDL cholesterol levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with HDL cholesterol levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of HDL cholesterol levels compared to the general population.
Source

Questions about rs12231737

What is rs12231737?

rs12231737 is a single position in the genome, in or near the TRAFD1 gene. Published research associates it with hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12231737 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12231737 come from?

GWAS Catalog, Biomedicines 2022, PMID:35884923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

HDL cholesterol levels (rs12231737). MyGeneLog™. https://www.mygenelog.com/variants/rs12231737

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