MYL2 · rs12231049
Where this position leads
Condition: Resistant Hypertension
What the study found
Who was studied 8,178 Korean ancestry cases, 9,558 Korean ancestry controls.
The effect Each copy of the G allele carried 0.83 times the odds of Hypertension (95% confidence interval 0.78-0.89); p = 8 × 10−9.
How common The G allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 12, band 12q24.11 — in an intron of MYL2.
What ClinVar records
Classification
Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-06-23.
ClinVar record 1270702 NM_000432.4(MYL2):c.403-244T>C
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs12231049 is a single position in the genome, in or near the MYL2 gene. Published research associates it with hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Resistant Hypertension. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nutrients 2020, PMID:32709000. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hypertension (rs12231049). MyGeneLog™. https://www.mygenelog.com/variants/rs12231049