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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 21,297 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 43.8 mm3 higher; p = 1 × 10−15.
Where it sits Chromosome 10, band 10q26.13 — in an intron of EEF1AKMT2.
What each result means
C/CTwo copies of the version the research linked to Total hippocampal volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Total hippocampal volume. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Total hippocampal volume. This is the starting point the study compared everyone against.
Molecular psychiatry · 2020 · PMID 30279459 · open access
Questions about rs12218858
What is rs12218858?
rs12218858 is a single position in the genome, in or near the FAM175B gene. Published research associates it with total hippocampal volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12218858 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12218858 come from?
GWAS Catalog, Mol Psychiatry 2018, PMID:30279459. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total hippocampal volume (rs12218858). MyGeneLog™. https://www.mygenelog.com/variants/rs12218858